Dextromethorphan-Associated Neurotoxicity with Cerebellar Edema (DANCE) syndrome
Toxicosis
Iatrogenic diseases
General description
Dextromethorphan-Associated Neurotoxicity with Cerebellar Edema (DANCE) syndrome is a central nervous system disorder caused by dextromethorphan, a common antitussive medication. Dextromethorphan is a morphinan derivative with sedative and dissociative properties, used as a cough suppressant. It works by directly acting on the cough center in the medulla oblongata, suppressing the cough reflex.
Cerebellar lesion
MRI shows near symmetric hyperintensity in the cerebellar hemisphere on T2-weighted images accompanied by diffusion restriction.
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Cerebral white matter lesion
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